Compromised Collagen Formation & Hernia Development

by  on  in Collagen

The Role of Collagen in Hernia Genesis

 

  • Lars Nannestad Jorgensen
  • Finn Gottrup
Chapter
  • 52Downloads

Abstract

There is a discrepancy between the number of publications on hernia in general and those addressing the role of collagen as an important pathophysiological factor in the development of hernia. On Medline, the search for “hernia” produces more than 14,000 references, whereas the search for “hernia” plus “collagen” or “connective tissue” yields only 25. This difference clearly illustrates that the pathophysiological factors for hernia formation have yet to be fully defined. Many papers address different surgical techniques and their outcomes. The aim of this chapter is to give an overview of the literature on the role of collagen in hernia genesis, with a focus on biomechanical tissue features.

Keywords

Inguinal Hernia Internal Ring Rectus Sheath Groin Hernia Transversalis Fascia 

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

978-1-4419-8574-3_19

References

  1. Bellón JM, Buján J, Honduvilla NG, et al. Study of biochemical substrate and role of metalloproteinases in fascia transversalis from hernial processes. Eur J Clin Invest. 1997;27:510–516.PubMedCrossRefGoogle Scholar
  2. Conner WT, Peacock EE Jr. Some studies on the etiology of inguinal hernia. Am J Surg. 1973;126:732–735.PubMedCrossRefGoogle Scholar
  3. Peacock EE Jr, Madden JW. Studies on the biology and treatment of recurrent inguinal hernia: II. Morphological changes. Ann Surg. 1974; 179:567–571.PubMedCrossRefGoogle Scholar
  4. Uden A, Lindhagen T. Inguinal hernia in patients with congenital dislocation of the hip. A sign of general connective tissue disorder. Acta Orthop Scand. 1988;59:667–668.PubMedCrossRefGoogle Scholar
  5. Jessee EF, Owen DS, Sagar KD. The benign hypermobile joint syndrome. Arthntis Rheum. 1980;23:1053–1056.CrossRefGoogle Scholar
  6. Friedman DW, Boyd CD, Norton P, et al. Increases in type III collagen gene expression and protein synthesis in patients with inguinal hernias. Ann Surg. 1993;218:754–760.PubMedCrossRefGoogle Scholar
  7. Wirtschafter ZT, Bentley JP. Hernias as a collagen maturation defect. Ann Surg. 1969;160:852–859.CrossRefGoogle Scholar
  8. Read RC. Attenuation of the rectus sheath in inguinal herniation. Am J Surg. 1970;120:610–614.PubMedCrossRefGoogle Scholar
  9. Wagh PV, Read RC. Collagen deficiency in rectus sheath of patients with inguinal herniation. Proc Soc Exp Biol Med. 1971;137:382–384.Google Scholar
  10. Pans A, Piérard GE, Albert A, et al. Adult groin hernias: new insight into their biomechanical characteristics. Eur J Clin Invest. 1997;27:863–868.PubMedCrossRefGoogle Scholar
  11. Wagh PV, Read RC. Defective collagen synthesis in inguinal herniation. Am J Surg. 1972;124:819–822.PubMedCrossRefGoogle Scholar
  12. Ajabnoor MA, Mokhtar AM, Rafee AA, et al. Defective collagen metabolism in Saudi patients with hernia. Ann Clin Biochem. 1992;29:430–436.PubMedGoogle Scholar
  13. Wagh PV, Leverich AP, Sun CN, et al. Direct inguinal herniation in men: a disease of collagen. J Surg Res. 1974;17:425–433.PubMedCrossRefGoogle Scholar
  14. White HJ, Sun CN, Read RC. Inguinal hernia: a true collagen disease. Lab Invest. 1977;36:359.Google Scholar
  15. Cannon DJ, Read RC. Metastatic emphysema: a mechanism for acquiring inguinal herniation. Ann Surg. 1981;194:270–278.PubMedCrossRefGoogle Scholar
  16. Cannon DJ, Casteel L, Read RC. Abdominal aortic aneurysm, Leriche’s syndrome, inguinal herniation, and smoking. Arch Surg. 1984;119: 387–389.PubMedCrossRefGoogle Scholar
  17. Lehnert B, Wadouh F. High coincidence of inguinal hernias and abdominal aortic aneurysms. Ann Vasc Surg. 1992;6:134–137.PubMedCrossRefGoogle Scholar
  18. Peacock EE Jr. Subcutaneous extraperitoneal repair of ventral hernias: a biological basis for fascial transplantation. Ann Surg. 1975;181:722–727.PubMedCrossRefGoogle Scholar
  19. Marks MG, Doillon C, Silver FH. Effects of fibroblasts and basic fibroblast growth factor on facilitation of dermal wound healing by type I collagen matrices. J Biomed Mater Res. 1991;25:683–696.PubMedCrossRefGoogle Scholar
  20. Agren MS, Jorgensen LN, Andersen M, et al. Matrix metalloproteinase 9 level predicts optimal collagen deposition during early wound repair in humans. Br J Surg. 1998;85:68–71.PubMedCrossRefGoogle Scholar
  21. Agren MS. Gelatinase activity during wound healing. Br J Dermatol. 1994;131:634–640.PubMedCrossRefGoogle Scholar
  22. Tarlton JF, Vickery CJ, Leaper DJ, et al. Postsurgical wound progression monitored by temporal changes in the expression of matrix metalloproteinase-9. Br J Dermatol. 1997;137:506–516.PubMedCrossRefGoogle Scholar
  23. Savage FJ, Lacombe DLP, Hembry RM, et al. Effect of colonic obstruction on the distribution of matrix metalloproteinases during anastomotic healing. Br J Surg. 1998;85:72–75.PubMedCrossRefGoogle Scholar
  24. Witte MB, Thornton FJ, Kiyama T, et al. Metalloproteinase inhibitors and wound healing: a novel enhancer of wound strength. Surgery. 1998;124:464–470.PubMedCrossRefGoogle Scholar
  25. Ashcroft GS, Horan MA, Herrick SE, et al. Age-related differences in the temporal and spatial regulation of matrix metalloproteinases (MMPs) in normal skin and acute cutaneous wounds of healthy humans. Cell Tissue Res. 1997;290:581–591.PubMedCrossRefGoogle Scholar
  26. Yager DR, Zhang L-Y, Liang H-X, et al. Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids. J Invest Dermatol. 1996; 107:743–748.PubMedCrossRefGoogle Scholar
  27. Ashcroft GS, Herrick SE, Tarnuzzer RW, et al. Human ageing impairs injury-induced in vivo expression of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and-2 proteins and mRNA. J Pathol. 1997; 183:169–176.PubMedCrossRefGoogle Scholar
  28. Pickett BP, Burgess LP, Livermore GH, et al. Tensile strength versus healing time for wounds closed under tension. Arch Otolaryngol Head Neck Surg. 1996;122:565–568.PubMedCrossRefGoogle Scholar

 

___
https://link.springer.com/chapter/10.1007/978-1-4419-8574-3_19